SACLAC

Description: SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML cell death, and induces apoptosis of AML cells, and is used in the study of acute myeloid leukemia and cancer. Target: Bcl-2 Family, Apoptosis, Caspase, LPL Receptor. Smiles: [C@H]([C@@H](CCCCCCCCCC CCCCC)O)(NC(CCl)=O)CO. References: Pearson JM,et al. Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. Mol Cancer Res. 2020 Mar,18(3):352-363.