SACLAC

SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Cay-9003925). It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 µM. SACLAC (10 and 20 µM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.Formal Name: 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-acetamide. CAS Number: 2248703-42-4. Molecular Formula: C20H40ClNO3. Formula Weight: 378.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: ClCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O. InChi Code: InChI=1S/C20H40ClNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(24)18(17-23)22-20(25)16-21/h18-19,23-24H,2-17H2,1H3,(H,22,25)/t18-,19+/m0/s1. InChi Key: XDHVKWVHTCINMB-RBUKOAKNSA-N.