SABRAC

SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM). It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 µM.Formal Name: 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-acetamide. CAS Number: 886212-98-2. Molecular Formula: C20H40BrNO3. Formula Weight: 422.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: BrCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O. InChi Code: InChI=1S/C20H40BrNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(24)18(17-23)22-20(25)16-21/h18-19,23-24H,2-17H2,1H3,(H,22,25)/t18-,19+/m0/s1. InChi Key: KXLZSKTVZMRRCY-RBUKOAKNSA-N.