S3QEL-2

S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function. It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic beta-cells and decreases HIF-1alpha induction in response to hypoxia.Formal Name: 1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. CAS Number: 890888-12-7. Molecular Formula: C19H25N5. Formula Weight: 323.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: slightly soluble. lambdamax: 243, 298 nm. SMILES: CCCN(CCC)C1=C(C=NN2C3=CC(C)=C(C)C=C3)C2=NC=N1. InChi Code: InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3. InChi Key: MGIAJZSCNPODRR-UHFFFAOYSA-N.