(S)-MCPG

(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs. (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced intracellular calcium increases in CHO cells expressing mGluR1alpha (IC50 = 120 µM). (S)-MCPG also has agonist activity at mGluR2. It induces long-term depression in the rat hippocampal dentate gyrus, an effect that can be blocked by the mGluR2 antagonist MCCG, and blocks long-term potentiation in the CA1 region.Formal Name: (alphaS)-alpha-amino-4-carboxy-alpha-methyl-benzeneacetic acid. CAS Number: 150145-89-4. Synonyms: (+)-alpha-methyl-4-Carboxyphenylglycine, (S)-alpha-methyl-4-Carboxyphenylglycine, (+)-MCPG. Molecular Formula: C10H11NO4. Formula Weight: 209.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. lambdamax: 232 nm. SMILES: C[C@@](N)(C(O)=O)C1=CC=C(C(O)=O)C=C1. InChi Code: InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15). InChi Key: DNCAZYRLRMTVSF-UHFFFAOYSA-N.