(S)-Flurbiprofen

(S)-Flurbiprofen is the COX-active enantiomer of the non-selective COX inhibitor flurbiprofen (Cay-70250) with IC50 values of 0.48 and 0.47 µM for COX-1 and COX-2, respectively, in guinea pig whole blood. It inhibits the release of 6-keto prostaglandin F1alpha (6-keto-PGF1alpha, Cay-15210) and thromboxane B2 (TXB2, Cay-19030) from rat whole blood, gastric mucosa, lung, and jejunal tissue ex vivo in a dose-dependent manner. (S)-Flurbiprofen (1 nM) inhibits basal and bradykinin-, serotonin-, and histamine-stimulated prostaglandin E2 (PGE2) release from isolated skin flaps of rat lower hind paws. It also inhibits release of the neuroinflammatory marker calcitonin gene-related peptide (CGRP, Cay-24405, Cay-24725, Cay-24728) when used at a concentration of 1 µM. In vivo, (S)-flurbiprofen reduces the number of flinches per minute in the formalin test in rats, indicating antinociceptive activity.Formal Name: (S)-(+)-2-fluoro-alpha-methyl-4-biphenylacetic acid. CAS Number: 51543-39-6. Molecular Formula: C15H13FO2. Formula Weight: 244.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.9 mg/ml. lambdamax: 247 nm. SMILES: FC1=CC([C@@H](C(O)=O)C)=CC=C1C2=CC=CC=C2. InChi Code: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18). InChi Key: SYTBZMRGLBWNTM-UHFFFAOYSA-N.