(S)-CR8

Description: (S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor. Target: Others. Smiles: C(C)(C)N1C=2C(=C(NCC3=CC=C(C=C3)C4=CC=CC=N4)N=C(N[C@@H](CC)CO)N2)N=C1. References: Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouze C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, Fautrel A, Mrug M, Wallace DP, Tran PV, Trudel M, Bukanov NO, Ibraghimov-Beskrovnaya O, Meijer L. Casein kinase 1epsilon and 1alpha as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. Am J Physiol Renal Physiol. 2018 Mar 14. doi: 10.1152/ajprenal.00489.2017. [Epub ahead of print] PubMed PMID: 29537311.