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Zu "K02087" wurden 188 Artikel gefunden!
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Artikelnummer: NSJ-RQ5499
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CDC2, Cell Division Cycle 2, is also known as CDK1 (Cyclin-dependent Kinase 1). CDC2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor that induces entry into mitosis and is universal among eukaryotes. In HeLa cells CDC2 is...
Schlagworte: | Anti-CDK1, Anti-CDC2, Anti-p34 protein kinase, Anti-Cyclin-dependent kinase 1, Anti-Cell division protein kinase 1,... |
Anwendung: | WB, IHC (paraffin), FC |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Artikelnummer: Cay38526-10
AZD 5597 is a cyclin-dependent kinase 1 (Cdk1) and Cdk2 inhibitor (IC50 = 0.002 µM for both). It inhibits LoVo cell proliferation (IC50 = 0.039 µM). In vivo, AZD 5597 (15 mg/kg) reduces tumor volume in an SW620 colon adenocarcinoma mouse xenograft model.Formal Name:...
Schlagworte: | [4-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidi... |
Anwendung: | Cdk1 / Cdk2 inhibitor |
CAS | 924641-59-8 |
MW: | 437.5 D |
ab 158,00 €
Artikelnummer: ELK-ELK2253.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CDK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CDK1. Next,...
Schlagworte: | CDK1, CDC2, p34 protein kinase, Cyclin-dependent kinase 1, Cell division protein kinase 1, Cell division control protein 2... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay10398-1
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of...
Schlagworte: | 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone |
Anwendung: | Cdc2 kinase inhibitor |
CAS | 300801-52-9 |
MW: | 249.3 D |
ab 31,00 €
Artikelnummer: AG-MR-C0002-M005
Soluble in DMSO, ethanol or methanol. Stock solutions can be made up to 10 mM in DMSO. (S)-enantiomer of (R)-roscovitine (Prod. No. MR-C0001). Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking...
Schlagworte: | 6-Benzylamino-2-(S)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
Anwendung: | CDK1 inhibitor |
CAS | 186692-45-5 |
MW: | 354,5 D |
ab 116,00 €
Artikelnummer: Cay15149-1
Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling. It also...
Schlagworte: | 5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone |
Anwendung: | CDK1 inhibitor |
CAS | 872573-93-8 |
MW: | 351.4 D |
ab 50,00 €
Artikelnummer: Cay13317-5
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6102 is...
Schlagworte: | 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-benzenesulfonamide |
Anwendung: | CDK1 and CDK2 Inhibitor |
CAS | 444722-95-6 |
MW: | 402.5 D |
ab 73,00 €
Artikelnummer: Cay14155-5
Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 µM) and cyclin-dependent kinases 1 and 5 (IC50 =...
Schlagworte: | C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one |
Anwendung: | GSK-3 inhibitor, CDK1/5 inhibitor |
CAS | 479-41-4 |
MW: | 262.3 D |
ab 82,00 €
Artikelnummer: AG-CR1-3515-M005
Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at...
Schlagworte: | (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one |
Anwendung: | CDK1 inhibitor, Apoptosis inducer |
CAS | 872573-93-8 |
MW: | 351,5 D |
ab 33,00 €
Artikelnummer: AG-CR1-0036-M001
Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor, Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM), GSK-3beta (glycogen synthase kinase-3beta) inhibitor, Apoptosis inhibitor, Apoptosis inducer, Angiogenesis inhibitor.
Schlagworte: | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
Anwendung: | CDK inhibitor |
CAS | 237430-03-4 |
MW: | 293,3 D |
ab 44,00 €
Artikelnummer: AG-MR-C0001-M025
Soluble in DMSO or ethanol. Slightly soluble in water. Stock solutions can be made up to 10 mM in DMSO. Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer...
Schlagworte: | Seliciclib, CYC201, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
Anwendung: | Cyclin dependent kinase inhibitor |
CAS | 186692-46-6 |
MW: | 354,5 D |
220,00 €
Artikelnummer: Cay14579-5
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of...
Schlagworte: | NG 60, (2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
Anwendung: | CDK inhibitor |
CAS | 212844-53-6 |
MW: | 388.9 D |
ab 43,00 €