RWJ 67657

RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 µM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS (IC50s = 3 and 11 nM, respectively) and inhibits TNF-alpha production in LPS-treated mice and rats. RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4 nM). It is commonly used to study the roles of p38alpha and p38beta in cellular and whole animal systems.Formal Name: 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol. CAS Number: 215303-72-3. Synonyms: JNJ-3026582. Molecular Formula: C27H24FN3O. Formula Weight: 425.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 241, 269 nm. SMILES: FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)N(CCCC4=CC=CC=C4)C(C#CCCO)=N2. InChi Code: InChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2. InChi Key: QSUSKMBNZQHHPA-UHFFFAOYSA-N.