Rp-8-CPT-Cyclic AMP (sodium salt)

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP (Cay-12011) and Rp-cyclic AMPS (Cay-16985). It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II. By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.Formal Name: 8-[(4-chlorophenyl)thio]-adenosine cyclic 3',5'-[hydrogen (R)-phosphorothioate], monosodium salt. CAS Number: 221905-35-7. Synonyms: Rp-8-CPT-cAMP. Molecular Formula: C16H14ClN5O5PS2 . Na. Formula Weight: 509.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 275 nm. SMILES: O[C@H]1[C@H](N2C(SC3=CC=C(Cl)C=C3)=NC4=C2N=CN=C4N)O[C@H]5[C@H]1O[P@@](OC5)([S-])=O.[Na+]. InChi Code: InChI=1S/C16H15ClN5O5PS2.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12,/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20),/q,+1/p-1/t9-,11-,12-,15-,28-,/m1./s1. InChi Key: AWXMSJRRXLCVMW-ALHPSJIMSA-M.