Zu "K04345" wurden 146 Artikel gefunden!
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H-89 (hydrochloride)
Artikelnummer: Cay10010556-10
Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. H-89 is a potent, cell permeable inhibitor of PKA that demonstrates an IC50 value of 0.14 µM and a Ki value of 48 nM in standard...
| Schlagworte: | 5-Isoquinolinesulfonamide, Protein Kinase Inhibitor H-89,... |
| Anwendung: | PKA inhibitor |
| CAS | 130964-39-5 |
| MW: | 519.3 D |
ab 76,00 €
Anti-Recombinant PRKACA, clone 8A3
Artikelnummer: E-AN300927L.100
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free...
| Schlagworte: | Anti-PRKACA, Anti-cAMP-dependent protein kinase catalytic subunit alpha, Recombinant PRKACA Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
Anti-phospho-PKA C (Thr197) / PRKACA/PRKACB/PRKACG, clone...
Artikelnummer: NSJ-FY13272
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-PKA C (Thr197) antibody detects Protein kinase A catalytic subunit phosphorylated at threonine 197, encoded by PRKACA, PRKACB, and PRKACG. Protein kinase A catalytic subunit is the enzymatic...
| Schlagworte: | Anti-phospho-PRKACG, Anti-phospho-cAMP-dependent protein kinase catalytic subunit gamma, Phospho-PKA C (Thr197) Antibody /... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
PKA Inhibitor (5-24) (trifluoroacetate salt)
Artikelnummer: Cay15996-1
PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein. It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite. The prominent...
| Schlagworte: | PKI (5-24), Protein Kinase A Inhibitor (5-24),... |
| Anwendung: | cAMP-dependent protein kinase (PKA) inhibitor |
| MW: | 2222.4 D |
ab 114,00 €
H89
Artikelnummer: LKT-H0003.1
Selective potent inhibitor of cAMP-dependent protein kinase (PKA).
| Schlagworte: | N-[2-[P-Bromocinnamylamino]-ethyl)-5-isoquinolinesulfonmide |
| Anwendung: | PKA inhibitor |
| CAS | 127243-85-0 |
| MW: | 446,36 D |
ab 77,00 €
8-bromo Cyclic AMP (sodium salt)
Artikelnummer: Cay14431-25
8-bromo Cyclic AMP is an activator of protein kinase A (PKA) with a half-maximal activation (Ka) value of 0.05 µM. It is selective for PKA over cGMP-dependent protein kinase (PKG, Ka = 5.8 µM) and is more resistant to hydrolysis by phosphodiesterases (PDEs) compared with cAMP (Cay-18820). 8-bromo Cyclic AMP inhibits...
| Schlagworte: | 8-bromo-cAMP, 8-Bromoadenosine 3',5'-cyclic monophosphate, 8-bromo-cyclic 3',5'-(hydrogen phosphate)-adenosine, monosodium... |
| Anwendung: | cAMP analog, PKA activator |
| CAS | 76939-46-3 |
| MW: | 430.1 D |
ab 60,00 €
KT 5720
Artikelnummer: Cay10011011-50
Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive...
| Schlagworte: | 2,3,9,10,11,12-hexahydro-10S-hydroxy-9-methyl-1-oxo-9R,12S-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzo... |
| Anwendung: | PKA inhibitor |
| CAS | 108068-98-0 |
| MW: | 537.6 D |
ab 126,00 €
Anti-PKA gamma (catalytic subunit)
Artikelnummer: ARG65764.100
Protein function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. [The UniProt Consortium]
| Schlagworte: | Anti-PRKACG, Anti-PKA C-gamma, EC=2.7.11.11, Anti-cAMP-dependent protein kinase catalytic subunit gamma |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
658,00 €
Cyclic AMP
Artikelnummer: Cay18820-1
Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors. cAMP activates protein kinase A and the exchange proteins activated by cAMP...
| Schlagworte: | Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 143670, NSC 94017, cyclic 3',5'-(hydrogen... |
| Anwendung: | PKA activator |
| CAS | 60-92-4 |
| MW: | 329.2 D |
ab 83,00 €
8-CPT-Cyclic AMP (sodium salt)
Artikelnummer: Cay12011-50
8-CPT-Cyclic AMP is a lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG (Ka = 0.05 and 0.11 µM, respectively). 8-CPT-cAMP inhibits cyclic GMP-specific phosphodiesterase (PDE VA), cyclic GMP-inhibited phosphodiesterase (PDE III), and cyclic AMP-specific phosphodiesterase...
| Schlagworte: | 8-(p-Chlorophenylthio)-cAMP, 8-CPT-cAMP, 8-[(4-chlorophenyl)thio]-cyclic 3',5'-(hydrogen phosphate)-adenosine, monosodium... |
| Anwendung: | PKA/PKG activator |
| CAS | 93882-12-3 |
| MW: | 493.8 D |
ab 89,00 €
H-7 (hydrochloride)
Artikelnummer: Cay21434-5
H-7 is a non-selective inhibitor of protein kinases (PKs, IC50s = 20, 36, 7, and 420 µM for PKC, A, G, and M, respectively). It has been widely used to characterize the functional roles of PKC in a multitude of cellular processes.Formal Name: 5-[(2-methyl-1-piperazinyl)sulfonyl]-isoquinoline, dihydrochloride. CAS...
| Schlagworte: | 5-[(2-methyl-1-piperazinyl)sulfonyl]-isoquinoline, dihydrochloride |
| Anwendung: | ATP-competitive Ser/Thr kinase inhibitor |
| CAS | 108930-17-2 |
| MW: | 364.3 D |
ab 89,00 €
Kemptide
Artikelnummer: Cay15555-1
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA) as it carries the recognition and phosphorylation site of PKA. Various cultured cells can catalyze the phosphorylation of kemptide in the presence of extracellular ATP and cAMP (Kms = 3-4 µM) with plasma...
| Schlagworte: | NSC 332190 |
| Anwendung: | PKA substrate |
| CAS | 65189-71-1 |
| MW: | 771.9 D |
ab 69,00 €