Roxadustat

Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.Formal Name: N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine. CAS Number: 808118-40-3. Synonyms: ASP1517, FG-4592. Molecular Formula: C19H16N2O5. Formula Weight: 352.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 223, 261, 314, 333 nm. SMILES: OC1=C(C(NCC(O)=O)=O)N=C(C)C2=C1C=CC(OC3=CC=CC=C3)=C2. InChi Code: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23). InChi Key: YOZBGTLTNGAVFU-UHFFFAOYSA-N.