Roridin E

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively). Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM) and inhibits proliferation in a panel of additional cancer cell lines (IC50s = 50s = 1.74-7.68 nM). Roridin E inhibits the growth of P. falciparum (EC50 = 0.15 ng/ml), induces phytotoxicity in duckweed and kudzu, and is toxic to mice (LD50 = 10 mg/kg, i.p.). Roridin E is also produced by the plant B. coridifolia, which is associated with livestock poisoning in South America.Formal Name: (2'E,7'R)-2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1R)-1-hydroxyethyl]-verrucarin A. CAS Number: 16891-85-3. Molecular Formula: C29H38O8. Formula Weight: 514.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble, Methanol: soluble. SMILES: CC1=C[C@]2([H])[C@@]3([C@]4(C)[C@@]5(OC5)[C@](C[C@H]4OC(/C=C\C=C\[C@](OCC/C(C)=C/C(OC3)=O)([H])[C@H](O)C)=O)([H])O2)CC1. InChi Code: InChI=1S/C29H38O8/c1-18-9-11-28-16-34-26(32)14-19(2)10-12-33-21(20(3)30)7-5-6-8-25(31)37-22-15-24(36-23(28)13-18)29(17-35-29)27(22,28)4/h5-8,13-14,20-24,30H,9-12,15-17H2,1-4H3/b7-5+,8-6-,19-14+/t20-,21-,22-,23-,24-,27-,28-,29+/m1/s1. InChi Key: KEEQQEKLEZRLDS-FLGSVKSYSA-N.