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NVP-AEW541 (hydrochloride)
NVP-AEW541 (hydrochloride)

Artikelnummer: Cay13641-1

Insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase whose activation leads to angiogenesis as well as cell proliferation, survival, transformation, and metastasis. IGF-1R signaling has been implicated in the development and progression of cancer. NVP-AEW541 is a selective IGF-1R kinase...
Schlagworte: 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride
Anwendung: IGF-1R kinase inhibitor
MW: 512.5 D
ab 82,00 €
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Human IGF1R (Insulin Like Growth Factor 1 Receptor) CLIA Kit
Human IGF1R (Insulin Like Growth Factor 1 Receptor) CLIA Kit

Artikelnummer: G-HUES00307.96

ELISA Type: CLIA. Sensitivity: 46.875 pg/mL. Range: 78.125--5000 pg/mL. Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and...
Schlagworte: IGF1R, EC=2.7.10.1
Anwendung: CLIA
Reaktivität: Human
629,00 €
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Human IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA Kit
Human IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA...

Artikelnummer: G-HUES01638.96

ELISA Type: Sandwich. Sensitivity: 0.188ng/mL. Range: 0.313--20ng/mL. Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival...
Schlagworte: IGF1R, EC=2.7.10.1
Anwendung: Sandwich ELISA
Reaktivität: Human
566,00 €
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Anti-phospho-IGF1-Receptor (Tyr1316), clone 2B9
Anti-phospho-IGF1-Receptor (Tyr1316), clone 2B9

Artikelnummer: 0128-100

Schlagworte: Anti-phospho-IGF1R (pY1316)
Anwendung: WB, ELISA
Reaktivität: Human
349,00 €
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NVP-ADW742
NVP-ADW742

Artikelnummer: Cay18390-1

NVP-ADW742 is an insulin-like growth factor 1 receptor (IGF-1R) inhibitor with an IC50 value of 0.17 µM. It exhibits 6-fold greater selectivity for IGF-1R over the insulin receptor (InsR) kinase and minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210. NVP-ADW742 has been shown to inhibit...
Schlagworte: ADW742, GSK552602A,...
Anwendung: IGF-1R inhibitor
CAS 475488-23-4
MW: 453.6 D
ab 44,00 €
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Linsitinib
Linsitinib

Artikelnummer: Cay17708-5

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
Schlagworte: OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol
Anwendung: IGF-1R & InsR kinase inhibitor
CAS 867160-71-2
MW: 421.5 D
ab 44,00 €
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GSK1904529A
GSK1904529A

Artikelnummer: Cay29155-25

GSK1904529A is a dual inhibitor of the insulin receptor (InsR) and insulin-like growth factor 1 receptor (IGF-1R) kinases (IC50s = 25 and 27 nM, respectively, in a cell-free assay). It selectively inhibits InsR and IGF-1R kinases over a panel of 45 serine/threonine and tyrosine kinases (IC50s = >1 µM for all)....
Schlagworte: N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-p...
Anwendung: Insulin receptor / IGF-1R dual inhibitor
CAS 1089283-49-7
MW: 852 D
ab 32,00 €
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Anti-IGF1 receptor (C-term), clone 7G11
Anti-IGF1 receptor (C-term), clone 7G11

Artikelnummer: 0198-100

Schlagworte: Anti-IGF1R, Anti-CD221, EC=2.7.10.1
Anwendung: WB
Reaktivität: Human
349,00 €
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Phospho-IGF-1R Antibody Duo (Total, pY1161)
Phospho-IGF-1R Antibody Duo (Total, pY1161)

Artikelnummer: ARG30240.001

Protein function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
Schlagworte: Anti-phospho-IGF1R, EC=2.7.10.1
Anwendung: IF, ICC, WB
Reaktivität: Rat
512,00 €
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BMS 754807
BMS 754807

Artikelnummer: Cay17505-1

BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
Schlagworte: 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr...
Anwendung: IGF-1R / InsR inhibitor
CAS 1001350-96-4
MW: 461.5 D
ab 44,00 €
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AG-1024
AG-1024

Artikelnummer: Cay14833-1

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic...
Schlagworte: AGS 200, Tyrphostin AG-1024, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile
Anwendung: IGF-1R inhibitor
CAS 65678-07-1
MW: 305.2 D
ab 49,00 €
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AZD 3463
AZD 3463

Artikelnummer: Cay26172-1

AZD 3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and the insulin growth factor-1 receptor (IGF-1R). It inhibits ALK with an IC50 value of 15 nM. It inhibits the proliferation of neuroblastoma cells with wild-type (WT) ALK (IC50s = 2.8-21.3 µM) and ALK with the activating mutations ALKF1174L and ALKD1091N...
Schlagworte: N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
Anwendung: ALK inhibitor, IGF1R inhibitor
CAS 1356962-20-3
MW: 449 D
ab 32,00 €
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