Zu "K05087" wurden 200 Artikel gefunden!
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Anti-IGF-1R, Human, mAb 1B1
Artikelnummer: HYC-HM2340-100UG
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor |
| Anwendung: | FC, ELISA, IF |
| Spezies-Reaktivität: | human |
ab 139,00 €
Anti-Recombinant IGF1 Receptor, clone 6A5
Artikelnummer: E-AN301096L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor I receptor, Anti-Insulin-like growth factor 1 receptor, Recombinant IGF1... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
Anti-IGF1R / Insulin-like growth factor 1 receptor
Artikelnummer: NSJ-FY12364
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The IGF1R antibody targets Insulin-like growth factor 1 receptor, a transmembrane tyrosine kinase receptor encoded by the IGF1R gene. This receptor mediates the biological effects of insulin-like growth factors IGF1 and IGF2, regulating...
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, IGF1R Antibody /... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Human IGF1 Receptor ELISA Kit
Artikelnummer: ARG81741.96
Protein function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | IGF1R, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
JB-1 (trifluoroacetate salt)
Artikelnummer: Cay44046-1
JB-1 is an insulin-like growth factor 1 receptor (IGF-1R) antagonist and a cyclic derivative of IGF-1 (60-70). It inhibits IGF-1-induced IGF-1R autophosphorylation and proliferation in BALB/c 3T3 cells overexpressing IGF-1R when used at a concentration of 1 µg/ml. Intracerebroventricular administration of JB-1 (4...
| Schlagworte: | Cyclic [CYAAPLKPAKSC], cyclo(CYAAPLKPAKSC), IGF-1 Analog |
| Anwendung: | IGF-1R antagonist, cyclic IGF-1 derivative |
| MW: | 1249.51 D |
ab 76,00 €
NVP-AEW541 (hydrochloride)
Artikelnummer: Cay13641-1
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2,...
| Schlagworte: | 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride |
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 512.5 D |
ab 126,00 €
Anti-IGF1R/CD221 Monoclonal Recombinant Antibody
Artikelnummer: E-AN300050P.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | IGF1R, EC=2.7.10.1, Recombinant IGF1R/CD221 Monoclonal Antibody |
| Anwendung: | FCM, ICC/IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
462,00 €
Anti-Phospho-IGF1R (Tyr1131)/Insulin Receptor beta...
Artikelnummer: E-AN300051L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | IGF1R, EC=2.7.10.1, Recombinant Phospho-IGF1R (Tyr1131)/Insulin Receptor beta (Tyr1146) Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
BMS 754807
Artikelnummer: Cay17505-1
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 69,00 €
Linsitinib
Artikelnummer: Cay17708-5
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 62,00 €
NVP-ADW742
Artikelnummer: Cay18390-1
NVP-ADW742 is an insulin-like growth factor 1 receptor (IGF-1R) inhibitor with an IC50 value of 0.17 µM. It exhibits 6-fold greater selectivity for IGF-1R over the insulin receptor (InsR) kinase and minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210. NVP-ADW742 has been shown to inhibit...
| Schlagworte: | ADW742, GSK552602A,... |
| Anwendung: | IGF-1R inhibitor |
| CAS | 475488-23-4 |
| MW: | 453.6 D |
ab 57,00 €
OSI-906
Artikelnummer: LKT-O7333.5
IGF-1R and InsR inhibitor.
| Schlagworte: | OSI906, Linsitinib |
| Anwendung: | Insulin-like growth factor 1 receptor |
| CAS | 867160-71-2 |
| MW: | 421.49 D |
ab 136,00 €