Zu "K05087" wurden 129 Artikel gefunden!
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Anti-IGF1R / Insulin like growth factor 1 receptor
Artikelnummer: NSJ-F54940-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an...
| Schlagworte: | Anti-IGF1R, EC=2.7.10.1, IGF1R Antibody / Insulin like growth factor 1 receptor |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 326,00 €
Human IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA...
Artikelnummer: ELK-ELK3396.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IGF1R. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human IGF1R. Next,...
| Schlagworte: | IGF1R, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Mouse IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA...
Artikelnummer: ELK-ELK4938.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse IGF1R. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse IGF1R. Next,...
| Schlagworte: | Igf1r, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Rat IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA Kit
Artikelnummer: ELK-ELK7005.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat IGF1R. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat IGF1R. Next,...
| Schlagworte: | Igf1r, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
IGF-1R Reporter Assay System (human)
Artikelnummer: IB-IB29001
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | IGF1R, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
1.448,00 €
IGF-1R Reporter Assay System (human)
Artikelnummer: IB-IB29002
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | IGF1R, EC=2.7.10.1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.802,00 €
NVP-AEW541 (hydrochloride)
Artikelnummer: Cay13641-1
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2,...
| Schlagworte: | 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride |
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 512.5 D |
ab 109,00 €
BMS 754807
Artikelnummer: Cay17505-1
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 60,00 €
Linsitinib
Artikelnummer: Cay17708-5
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 54,00 €
Anti-phospho-IGF1-Receptor (Tyr1316), clone 2B9
Artikelnummer: 0128-100
| Schlagworte: | Anti-phospho-IGF1R (pY1316) |
| Anwendung: | WB, ELISA |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
383,00 €
NVP-ADW742
Artikelnummer: Cay18390-1
NVP-ADW742 is an insulin-like growth factor 1 receptor (IGF-1R) inhibitor with an IC50 value of 0.17 µM. It exhibits 6-fold greater selectivity for IGF-1R over the insulin receptor (InsR) kinase and minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210. NVP-ADW742 has been shown to inhibit...
| Schlagworte: | ADW742, GSK552602A,... |
| Anwendung: | IGF-1R inhibitor |
| CAS | 475488-23-4 |
| MW: | 453.6 D |
ab 48,00 €
Anti-IGF1 receptor (C-term), clone 7G11
Artikelnummer: 0198-100
| Schlagworte: | Anti-IGF1R, Anti-CD221, EC=2.7.10.1 |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
383,00 €