Zu "K05087" wurden 198 Artikel gefunden!
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Anti-IGF1R / Insulin-like growth factor 1 receptor
Artikelnummer: NSJ-FY12364
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The IGF1R antibody targets Insulin-like growth factor 1 receptor, a transmembrane tyrosine kinase receptor encoded by the IGF1R gene. This receptor mediates the biological effects of insulin-like growth factors IGF1 and IGF2, regulating...
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, IGF1R Antibody /... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-IGF-1R, Human, mAb 1B1
Artikelnummer: HYC-HM2340-100UG
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor |
| Anwendung: | FC, ELISA, IF |
| Spezies-Reaktivität: | human |
ab 139,00 €
Anti-Recombinant IGF1 Receptor, clone 6A5
Artikelnummer: E-AN301096L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | Anti-IGF1R, Anti-Insulin-like growth factor I receptor, Anti-Insulin-like growth factor 1 receptor, Recombinant IGF1... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
Human IGF1 Receptor ELISA Kit
Artikelnummer: ARG81741.96
Protein function: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | IGF1R, EC=2.7.10.1 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
JB-1 (trifluoroacetate salt)
Artikelnummer: Cay44046-1
JB-1 is an insulin-like growth factor 1 receptor (IGF-1R) antagonist and a cyclic derivative of IGF-1 (60-70). It inhibits IGF-1-induced IGF-1R autophosphorylation and proliferation in BALB/c 3T3 cells overexpressing IGF-1R when used at a concentration of 1 µg/ml. Intracerebroventricular administration of JB-1 (4...
| Schlagworte: | Cyclic [CYAAPLKPAKSC], cyclo(CYAAPLKPAKSC), IGF-1 Analog |
| Anwendung: | IGF-1R antagonist, cyclic IGF-1 derivative |
| MW: | 1249.51 D |
ab 73,00 €
![IGF1R/CD221[Biotin], His & Avi, Human](https://www.biomol.com/media/image/19/a7/81/GSC-Z04484-100_200x200.png "IGF1R/CD221[Biotin], His & Avi, Human")
IGF1R/CD221[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04484-100
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for...
| Schlagworte: | IGF1R, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor |
| Ursprungsart: | human |
| MW: | 105.8/23 kD |
ab 887,00 €
IGF1R/CD221, His & Avi, Human
Artikelnummer: GSC-Z05404-100
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for...
| Schlagworte: | IGF1R, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor |
| Ursprungsart: | human |
| MW: | 105.8/23 kD |
ab 524,00 €
Anti-IGF1R/CD221 Monoclonal Recombinant Antibody
Artikelnummer: E-AN300050P.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | IGF1R, EC=2.7.10.1, Recombinant IGF1R/CD221 Monoclonal Antibody |
| Anwendung: | FCM, ICC/IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
462,00 €
Anti-Phospho-IGF1R (Tyr1131)/Insulin Receptor beta...
Artikelnummer: E-AN300051L.100
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it...
| Schlagworte: | IGF1R, EC=2.7.10.1, Recombinant Phospho-IGF1R (Tyr1131)/Insulin Receptor beta (Tyr1146) Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
NVP-AEW541 (hydrochloride)
Artikelnummer: Cay13641-1
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2,...
| Schlagworte: | 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride |
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 512.5 D |
ab 122,00 €
BMS 754807
Artikelnummer: Cay17505-1
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
| Schlagworte: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
| Anwendung: | IGF-1R / InsR inhibitor |
| CAS | 1001350-96-4 |
| MW: | 461.5 D |
ab 67,00 €
Linsitinib
Artikelnummer: Cay17708-5
The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition....
| Schlagworte: | OSI-906, cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol |
| Anwendung: | IGF-1R & InsR kinase inhibitor |
| CAS | 867160-71-2 |
| MW: | 421.5 D |
ab 60,00 €