Ropinirole (hydrochloride)

Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay). It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson's disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson's disease motor dysfunction.Formal Name: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, monohydrochloride. CAS Number: 91374-20-8. Synonyms: SKF 101468A. Molecular Formula: C16H24N2O . HCl. Formula Weight: 296.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 250 nm. SMILES: O=C1NC2=CC=CC(CCN(CCC)CCC)=C2C1.Cl. InChi Code: InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15,/h5-7H,3-4,8-12H2,1-2H3,(H,17,19),1H. InChi Key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N.