Rofecoxib

Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 µM, respectively, for production of prostaglandin E2 (PGE2, Cay-14010) in CHO cells expressing the recombinant human enzymes. In vivo, rofecoxib inhibits carrageenan-induced paw edema and hyperalgesia (ID50s = 1.5 and 1.0 mg/kg, respectively), LPS-induced pyresis (ID50 = 0.24 mg/kg), and M. butyricum-induced arthritis (ID50 = 0.74 mg/kg/day per day) in rats. Formulations containing rofecoxib were previously used in the treatment of pain and arthritis.Formal Name: 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone. CAS Number: 162011-90-7. Synonyms: MK-966. Molecular Formula: C17H14O4S. Formula Weight: 314.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 284 nm. SMILES: O=C1OCC(C2=CC=C(S(C)(=O)=O)C=C2)=C1C3=CC=CC=C3. InChi Code: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3. InChi Key: RZJQGNCSTQAWON-UHFFFAOYSA-N.