Ro 67-7476

Description: Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. Target: GluR. Smiles: Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1. References: Hemstapat K et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006 Aug, 70(2), 616-26