RO-0335

Description: RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC50 = 1.1 nM) and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. Target: Reverse Transcriptase. Smiles: NS(=O)(=O)c1ccc(NC(=O)Cc2ccc(Br)c(Oc3cc(Cl)cc(c3)C#N)c2F)c(Cl)c1. References: Javanbakht H , Ptak R G , Chow E , et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor[J]. Antiviral Research, 2010, 86(2):212-219.