Rilmenidine hemifumarate

Description: Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and alpha2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells. Target: Apoptosis, Imidazoline Receptor. Smiles: C1CC1C(C2CC2)NC3=NCCO3.C1CC1C(C2CC2)NC3=NCCO3.C(=CC(=O)O)C(=O)O. References: Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000,13(6 Pt 2):106S-111S.