Zu "K04138" wurden 119 Artikel gefunden!
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CHO-K1/ADRA2A/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00281
Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 2A (ADRA2A) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.
| Schlagworte: | ADRA2A, Alpha-2A adrenoreceptor, Alpha-2A adrenergic receptor, Alpha-2 adrenergic receptor subtype C10 |
11.424,00 €
ST 91
Artikelnummer: Cay43562-10
ST 91 is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It induces cAMP accumulation in HEK293 cells expressing alpha2A-, alpha2B-, or alpha2C-ARs (EC50s = 155, 371, and 851 nM, respectively). ST 91 (100 nM) inhibits isoproterenol-induced relaxation in phenylephrine-precontracted isolated rat mesenteric...
| Schlagworte: | N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
| Anwendung: | alpha-2 adrenergic receptor agonist |
| CAS | 4749-61-5 |
| MW: | 253.77 D |
ab 118,00 €
Chlorpromazine (hydrochloride)
Artikelnummer: Cay16129-500
Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1a-, alpha2b-, and alpha2C-adrenergic, and M3...
| Schlagworte: | CPZ, 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, monohydrochloride |
| Anwendung: | 5-HT2-receptor, H1-receptor, dopamine D2-receptor, alpha2-adrenergic receptor antagonist |
| CAS | 69-09-0 |
| MW: | 355.3 D |
ab 49,00 €
Dexmedetomidine-d3 (tartrate)
Artikelnummer: Cay43801-1
An internal standard for the quantification of dexmedetomidine by GC- or LC-MS
| Schlagworte: | MPV 1440-d3, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl-2,2,2-d3]-1H-imidazole, 2R,3R-dihydroxybutanedioate |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, alpha2-adrenergic receptor agonist |
| MW: | 353.39 D |
ab 146,00 €
Medetomidine (hydrochloride)
Artikelnummer: Cay16454-10
Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...
| Schlagworte: | Domitor(R), MPV 785, 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 86347-15-1 |
| MW: | 236.7 D |
ab 93,00 €
Idazoxan (hydrochloride)
Artikelnummer: Cay41310-10
Idazoxan is an antagonist of alpha2-adrenergic receptors (alpha2-ARs) and imidazoline I1 and I2 receptors (IC50s = 69, 66, and 61 nM, respectively). It selectively binds to alpha2A- and alpha2C-ARs over alpha2B-ARs (Kds = 67, 69, and 407 nM, respectively), as well as alpha2-ARs over alpha1-ARs (IC50s = 0. and 4,000...
| Schlagworte: | RX 781094, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole, monohydrochloride |
| Anwendung: | Adrenergic receptor alpha antagonist |
| CAS | 79944-56-2 |
| MW: | 240.69 D |
ab 81,00 €
Medetomidine-d3 (hydrochloride)
Artikelnummer: Cay41734-1
Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: Ethanol: Sparingly Soluble: 1-10 mg/ml.
| Schlagworte: | MPV 785-d3, 5-[1-(2,3-dimethylphenyl)ethyl-2,2,2-d3]-1H-imidazole, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, sedative, alpha2-adrenergic receptor agonist |
| CAS | 1246820-20-1 |
| MW: | 239.76 D |
ab 221,00 €
Fendiline (hydrochloride)
Artikelnummer: Cay17295-1
Fendiline is an alpha2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects. Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and...
| Schlagworte: | gamma-phenyl-N-(1-phenylethyl)-benzenepropanamine, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor antagonist, L-type calcium channel blocker |
| CAS | 13636-18-5 |
| MW: | 351.9 D |
ab 185,00 €
Rauwolscine (hydrochloride)
Artikelnummer: Cay15596-100
Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...
| Schlagworte: | Isoyohimbine, NSC 407307, alpha-Yohimbine, (16beta,17alpha,20alpha)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester,... |
| Anwendung: | Selective, reversible alpha2-adrenergic receptor antagonist |
| CAS | 6211-32-1 |
| MW: | 390.9 D |
ab 56,00 €
(-)-Norepinephrine (bitartrate hydrate)
Artikelnummer: Cay16673-500
(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...
| Schlagworte: | Arterenol, Levarterenol, L-Noradrenaline, NE, 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol... |
| Anwendung: | Adrenergic receptor agonist, dopamine beta-hydroxylase metabolite |
| CAS | 108341-18-0 |
| MW: | 337.3 D |
ab 50,00 €
Clonidine (hydrochloride)
Artikelnummer: Cay15949-1
Clonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 61.66, 69.18, and 134.9 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively). It stimulates [35S]GTPgammaS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for alpha2A-,...
| Schlagworte: | ST 155, N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 4205-91-8 |
| MW: | 266.6 D |
ab 49,00 €
A2AR Agonist-1
Artikelnummer: Cay28414-500
A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1, Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively). It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases...
| Schlagworte: | JMF 1907, N-[2-(1H-indol-3-yl)ethyl]-adenosine |
| Anwendung: | Adenosine A2A receptor agonist, ENT1 inhibitor |
| CAS | 41552-95-8 |
| MW: | 410.4 D |
ab 145,00 €