Retinoic acid-d5

Description: Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARalpha/beta/gamma and a Kd of 17 nM for PPARbeta/delta. Retinoic acid, a metabolite of vitamin A, plays an important role in cell growth, differentiation and organ development. Retinoic acid acts by activating retinoic acid receptor alpha as an inhibitor of the transcription factor Nrf2. Smiles: C(=CC(=CC=CC(=CC(O)=O)C)C)C=1C(C)(C)CCC(C1C([2H])([2H])[2H])([2H])[2H]. References: Soni K, et al. Bioanalysis of Endogenous Isotretinoin in Altered and Unaltered Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Electrospray Ionization [published online ahead of print, 2022 Dec 25]. J Chromatogr Sci. 2022,bmac102.