Resolvin D1-d5

Resolvin D1-d5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay11182-10 10 µg -

6 - 10 Werktage*

226,00 €
Cay11182-25 25 µg -

6 - 10 Werktage*

508,00 €
 
Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of... mehr
Produktinformationen "Resolvin D1-d5"
Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Cay-10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples. Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.Formal Name: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21',22,22,22-d5 docosahexaenoic acid. CAS Number: 1881277-32-2. Synonyms: 17(S)-Resolvin D1-d5, RvD1-d5. Molecular Formula: C22H27D5O5. Formula Weight: 381.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): .05 mg/ml. lambdamax: 289, 302, 317 nm. SMILES: O[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1/i1D3,2D2. InChi Key: OIWTWACQMDFHJG-CLQVKFETSA-N.
Schlagworte: 17(S)-Resolvin D1-d5, RvD1-d5, 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21',22,22,22-d5 docosahexaenoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 11182

Eigenschaften

Anwendung: GC-MS, LC-MS, Internal standard
MW: 381.5 D
Formel: C22H27D5O5
Reinheit: >99% deuterated forms (d1-d5)
Format: Solution

Datenbank Information

CAS : 1881277-32-2| Passende Produkte
KEGG ID : K00460 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -80°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H350
P-Sätze: P201, P202, P210, P233, P240, P241, P242, P243, P280, P303+361+353, P308+313, P370+378, P403+235, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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