Racecadotril

Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan (Cay-15600). In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea. Formulations containing racecadotril have been used in the treatment of acute diarrhea.Formal Name: N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-glycine, phenylmethyl ester. CAS Number: 81110-73-8. Synonyms: Acetorphan. Molecular Formula: C21H23NO4S. Formula Weight: 385.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.16 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C(NCC(OCC1=CC=CC=C1)=O)C(CSC(C)=O)CC2=CC=CC=C2. InChi Code: InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25). InChi Key: ODUOJXZPIYUATO-UHFFFAOYSA-N.