(R)-ZINC3573

(R)-ZINC3573 is an agonist of MAS-related G protein-coupled receptor family member X2 (MRGPRX2). It induces beta-arrestin recruitment in a reporter assay using MRGPRX2-expressing HTLA cells and calcium mobilization in LAD 2 mast cells (EC50s = 0.74 and 1 µM, respectively). (R)-ZINC3573 is selective for MRGPRX2 over 21 other G protein-coupled receptors (GPCRs). It induces degranulation of LAD 2 mast cells in a concentration-dependent manner.Formal Name: N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3R-pyrrolidinamine. CAS Number: 2089389-15-9. Synonyms: (R)-ZINC72453573. Molecular Formula: C18H21N5. Formula Weight: 307.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: CN(C)[C@@H]1CCN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)C1. InChi Code: InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1. InChi Key: XKBSPAZCFAIBJL-OAHLLOKOSA-N.