(R,S,S)-VH 032

A diastereomer of VHL ligand 1, (R,S,S)-VH 032-containing molecules bind targets with the same affinity as PROTACs utilizing VHL ligand 1 but do not induce target degradation, have been used as controls for VHL ligand 1-containing PROTAC degradation activity. SMILES: O=C([C@@H](N)C(C)(C)C)N1[C@@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](C1)O. InChi Code: InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19+/m0/s1. InChi Key: ZLOXMSNKPDWMEF-YQVWRLOYSA-N