Zu "K03871" wurden 79 Artikel gefunden!
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Anti-VHL
Artikelnummer: ATA-HPA068954.100
Polyclonal Antibody against Human VHL, Gene description: von Hippel-Lindau tumor suppressor, Alternative Gene Names: VHL1, Validated applications: IHC, Uniprot ID: P40337, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Involved in the ubiquitination and...
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
382,00 €
VH 032 amide C7 Acid
Artikelnummer: Cay40447-10
VH 032 amide C7 acid is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal carboxylic acid conjugated via a heptyl linker to VHL ligand 1 (Cay-21591), which binds to von Hippel-Lindau (VHL) E3 ligase. It has been used in the synthesis of PROTACs targeting anaplastic...
| Schlagworte: | N-(8-carboxy-1-oxooctyl)-3-methyl-L-valyl-4R-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide |
| Anwendung: | PROTAC precursor |
| CAS | 2172819-76-8 |
| MW: | 600.8 D |
ab 108,00 €
(S,R,S)-AHPC-Me
Artikelnummer: TGM-T7752-100mg
Description: (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate...
| Schlagworte: | E3 ligase Ligand 1A, VHL ligand 2 |
| Anwendung: | Protac(R) reagent |
| CAS | 1948273-02-6 |
| MW: | 444.59 D |
ab 40,00 €
(S,R,S)-AHPC-Boc
Artikelnummer: TGM-T77916-50mg
Description: (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand for von Hippel-Lindau (VHL) protein recruitment in PROTAC technology [1]. Target: Others. Smiles: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)cc1
| Schlagworte: | VH032-Boc |
| Anwendung: | Protac(R) reagent |
| CAS | 1448189-98-7 |
| MW: | 530.68 D |
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GMB-475
Artikelnummer: TGM-T8488-100mg
Description: GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. Target: PROTACs,...
| Anwendung: | Protac(R) reagent |
| CAS | 2490599-18-1 |
| MW: | 861.93 D |
ab 88,00 €
VHL Protein, Human, Recombinant (His & Avi)
Artikelnummer: TGM-TMPY-06026-100ug
Description: VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
| Schlagworte: | RCA1, HRCA1, VHL1, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, pVHL |
| MW: | 27.5 kD |
ab 295,00 €
VH-298
Artikelnummer: TGM-TQ0121-100mg
Description: VH-298 is a potent inhibitor of VHL that stabilizes HIF-alpha and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-alpha protein-protein interaction downstream of HIF-alpha hydroxylation by PHD enzymes. Target: HIF, Ligand for E3 Ligase, Others. Smiles:...
| Anwendung: | Protac(R) reagent |
| CAS | 2097381-85-4 |
| MW: | 523.65 D |
ab 40,00 €
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
Artikelnummer: TGM-T17922-100mg
Description: (S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker. Target: Others, E3 Ligase Ligand-Linker Conjugate. Smiles:...
| Schlagworte: | E3 ligase Ligand-Linker Conjugates 5, VHL Ligand-Linker Conjugates 1 hydrochloride, VH032-PEG3-NH2 hydrochloride, VHL... |
| Anwendung: | Protac(R) reagent |
| CAS | 2097971-11-2 |
| MW: | 656.23 D |
ab 40,00 €
(S,R,S)-AHPC-C4-NH2
Artikelnummer: TGM-T18666-100mg
Description: (S,R,S)-AHPC-C4-NH2 is a custom-synthesized conjugate consisting of an E3 ligase ligand-linker, combining a VHL ligand based on (S,R,S)-AHPC with a linker specifically designed for EED-targeted PROTAC[1]. Target: Others. Smiles:...
| Schlagworte: | VH032-C4-NH2 |
| Anwendung: | Protac(R) reagent |
| CAS | 2138439-53-7 |
| MW: | 529.7 D |
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(S,R,S)-AHPC-Me-C10-NH2
Artikelnummer: TGM-T18669-100mg
Description: (S,R,S)-AHPC-Me-C10-NH2 is a synthesized chemical compound incorporating a VHL ligand and a linker, serving as an E3 ligase ligand-linker conjugate. It is utilized in PROTAC MS432[1]. Target: Others. Smiles:...
| Anwendung: | Protac(R) reagent |
| CAS | 2376139-52-3 |
| MW: | 627.88 D |
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VH032-PEG3-acetylene
Artikelnummer: TGM-T17230-2mg
Description: VH032-PEG3-acetylene is a synthesized conjugate compound comprising a VH032-based VHL ligand and a linker, intended for use in PROTAC technology as an E3 ligase ligand-linker conjugate[1]. Target: Others. Smiles:...
| Anwendung: | PROTAC precursor |
| CAS | 2098799-80-3 |
| MW: | 614.75 D |
55,00 €
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Artikelnummer: TGM-T15190-2mg
Description: (S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology. Target: Others. Smiles:...
| Schlagworte: | VHL Ligand-Linker Conjugates 4 hydrochloride, E3 ligase Ligand-Linker Conjugates 7, VH032-PEG4-NH2 hydrochloride |
| Anwendung: | Building block, PROTAC |
| CAS | 2064292-52-8 |
| MW: | 700.29 D |
31,00 €