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Anti-Recombinant VHL, clone C212032
Artikelnummer: E-AN302412L.100
Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible...
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor, Recombinant VHL Monoclonal Antibody |
| Anwendung: | WB, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse |
ab 171,00 €
Recombinant Human von Hippel-Lindau Protein Complex
Artikelnummer: SCC-MB7718
The von Hippel-Lindau (VHL) E3 ubiquitin ligase complex is one of the most extensively studied E3 ligase systems in targeted protein degradation and a major component utilized in PROTAC (proteolysis-targeting chimera) technology. Under normoxic conditions, the VHL complex selectively recognizes hydroxylated...
| Schlagworte: | VHL-ELOB-ELOC, VHL-ELOB-ELOC Complex, VHL E3 Ubiquitin Ligase Complex, von Hippel-Lindau Protein Complex, VHL-Elongin... |
| Ursprungsart: | human |
ab 182,00 €
Anti-VHL (recombinant antibody)
Artikelnummer: ABS-RN-17283.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): . Homologies: . IHC Verification: -. WB Verification: -. IP Verification: succeed. IF Verification: -. FC Verification: -. IP-MS Verification: -. Cross reactivity: Not tested. Sandwich ELISA...
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor, Recombinant VHL Antibody |
| Anwendung: | IP/ChIP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
VHL Protein, Human, Recombinant (MBP & His & Avi),...
Artikelnummer: TGM-TMPH-04541-100ug
Description: VHL Protein, Human, Recombinant (MBP & His & Avi), Biotinylated is expressed in E. coli. The accession number is P40337.
| Schlagworte: | VHL , pVHL , Protein G7 , von Hippel-Lindau disease tumor suppressor |
| MW: | 71.9 kD |
ab 166,00 €
(R,S,S)-VH 032
Artikelnummer: Cay44838-10
A diastereomer of VHL ligand 1, (R,S,S)-VH 032-containing molecules bind targets with the same affinity as PROTACs utilizing VHL ligand 1 but do not induce target degradation, have been used as controls for VHL ligand 1-containing PROTAC degradation activity. SMILES:...
| Schlagworte: | (4S)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-D-prolinamide |
| Anwendung: | VHL ligand 1 (PROTAC building block) diastereomer |
| CAS | 2230826-33-0 |
| MW: | 430.57 D |
ab 69,00 €
Anti-VHL Biotin Conjugate
Artikelnummer: NSJ-R35773BTN
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Von Hippel-Lindau tumor suppressor, VHL1
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor, VHL Antibody Biotin Conjugate |
| Anwendung: | WB, ELISA (peptide), EIA |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
836,00 €
VH298
Artikelnummer: Cay21133-1
VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL, Kd = 90 nM by isothermal titration calorimetry). VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-alpha (HIF-alpha) isoforms leading to proteasomal degradation. Through its effects on...
| Schlagworte: | (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyr... |
| Anwendung: | Cell-permeant VHL inhibitor |
| CAS | 2097381-85-4 |
| MW: | 523.7 D |
ab 58,00 €
VHL Ligand 1 (hydrochloride)
Artikelnummer: Cay21591-10
VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Cay-21622).Formal Name:...
| Schlagworte: | (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride |
| Anwendung: | Building block, PROTAC |
| CAS | 1448189-80-7 |
| MW: | 467 D |
ab 112,00 €
VHL Protein, Human, Recombinant (His & Avi)
Artikelnummer: TGM-TMPY-06026-100ug
Description: VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
| Schlagworte: | RCA1, HRCA1, VHL1, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, pVHL |
| MW: | 27.5 kD |
ab 280,00 €
Anti-VHL, Internal
Artikelnummer: ARG64033.100
Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in...
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-Von Hippel-Lindau disease tumor suppressor |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
871,00 €
Human Von Hippel Lindau / VHL ELISA Kit
Artikelnummer: G-HUFI01668.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-VHL
Artikelnummer: NSJ-R35773-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Von Hippel-Lindau tumor suppressor, VHL1 Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as...
| Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-Von Hippel-Lindau disease tumor suppressor, VHL Antibody |
| Anwendung: | WB, ELISA (peptide), EIA |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
836,00 €