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Zu "K03871" wurden 57 Artikel gefunden!
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Artikelnummer: ELK-ELK6800.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat vHL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat vHL. Next, Avidin...
Schlagworte: | Vhl, pVHL, von Hippel-Lindau disease tumor suppressor |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
365,00 €
ab 328,50 €
Artikelnummer: Cay38898-10
VH 032 linker 6 is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal alkyne conjugated via a PEG linker to VHL ligand 1 (Cay-21591), which binds to VHL E3 ligase. It has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells.Formal Name:...
Schlagworte: | (4R)-3-methyl-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]meth... |
Anwendung: | PROTAC precursor |
CAS | 2098799-80-3 |
MW: | 614.8 D |
ab 76,00 €
Artikelnummer: Cay21133-1
VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL, Kd = 90 nM by isothermal titration calorimetry). VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-alpha (HIF-alpha) isoforms leading to proteasomal degradation. Through its effects on...
Schlagworte: | (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyr... |
Anwendung: | Cell-permeant VHL inhibitor |
CAS | 2097381-85-4 |
MW: | 523.7 D |
ab 50,00 €
Artikelnummer: Cay21591-10
VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Cay-21622).Formal Name:...
Schlagworte: | (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride |
Anwendung: | Building block, PROTAC |
CAS | 1448189-80-7 |
MW: | 467 D |
ab 97,00 €
Artikelnummer: ARG64033.100
Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in...
Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-Von Hippel-Lindau disease tumor suppressor |
Anwendung: | ELISA, WB |
Wirt: | Goat |
Spezies-Reaktivität: | human, mouse, rat |
784,00 €
Artikelnummer: G-HUFI01668.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €
Artikelnummer: NSJ-R35773-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Von Hippel-Lindau tumor suppressor, VHL1 Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as...
Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-Von Hippel-Lindau disease tumor suppressor, VHL Antibody |
Anwendung: | WB, ELISA (peptide), EIA |
Wirt: | Goat |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Artikelnummer: E-AB-10671.120
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes...
Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor, VHL Polyclonal Antibody |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 71,00 €
Artikelnummer: NSJ-F49682-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein...
Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-Von Hippel-Lindau disease tumor suppressor, VHL Antibody |
Anwendung: | IHC, FC, WB, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 326,00 €
Artikelnummer: Cay26149-10
VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 (Cay-21591). VH 032 Linker 2 comprises the von Hippel-Lindau (VHL) ligand domain and the polyethylene glycol (PEG) linker of the bromodomain and extra terminal (BET) inhibitor-containing PROTACs MZ2...
Schlagworte: | E3 Ligase Ligand-Linker Conjugate 7,... |
Anwendung: | Building block, PROTAC |
CAS | 2064292-52-8 |
MW: | 700.3 D |
ab 77,00 €
Artikelnummer: Cay26151-1
VH 032 linker 3 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 (Cay-21591).Formal Name: (4R)-N-(5-amino-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, dihydrochloride, hydrate. Molecular Formula: C27H39N5O4S ....
Schlagworte: | (4R)-N-(5-amino-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide,... |
Anwendung: | Building block, PROTAC |
MW: | 602.6 D |
ab 43,00 €
Artikelnummer: ARG58776.100
Protein function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in...
Schlagworte: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
624,00 €