(R)-Equol

(R)-Equol is an agonist of estrogen receptor alpha (ERalpha) and active metabolite of the polyketide isoflavone daidzein (Cay-10005166). It is formed from daidzein by gut microbiota. (R)-Equol selectively induces ERalpha-mediated gene transcription over ERbeta-mediated transcription in HEC-1 cells expressing the human receptors in a reporter assay (EC50s = 66 and 330 nM, respectively).Formal Name: 3,4-dihydro-3R-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol. CAS Number: 221054-79-1. Synonyms: (+)-Equol, Isoequol. Molecular Formula: C15H14O3. Formula Weight: 242.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 225, 282 nm. SMILES: OC1=CC=C2C(OC[C@@H](C3=CC=C(O)C=C3)C2)=C1. InChi Code: InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2/t12-/m0/s1. InChi Key: ADFCQWZHKCXPAJ-LBPRGKRZSA-N. Origin: Synthetic.