Zu "K08550" wurden 441 Artikel gefunden!
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Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 101,00 €
Anti-Estrogen Receptor alpha, clone rESR1/9525
Artikelnummer: NSJ-V5879-100UG
0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...
| Schlagworte: | Anti-ESR1, Anti-ER-alpha, Anti-Estrogen receptor, Anti-Estradiol receptor, Anti-Nuclear receptor subfamily 3 group A... |
| Anwendung: | IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 375,00 €
Anti-Estrogen Receptor alpha, clone rESR1/9525
Artikelnummer: NSJ-V5879SAF-100UG
1 mg/ml in 1X PBS, BSA free, sodium azide free. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...
| Schlagworte: | Anti-ESR1, Anti-ER-alpha, Anti-Estrogen receptor, Anti-Estradiol receptor, Anti-Nuclear receptor subfamily 3 group A... |
| Anwendung: | IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
810,00 €
Anti-Estrogen Receptor alpha, clone MSVA-564R
Artikelnummer: NSJ-V6071-100UG
Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Estrogen receptor alpha (ESR1) is a ligand-activated nuclear hormone receptor that regulates gene transcription in response to estrogen signaling and plays a central role in the growth and differentiation of hormone-responsive tissues. Estrogen receptor alpha...
| Schlagworte: | Anti-ESR1, Anti-ER-alpha, Anti-Estrogen receptor, Anti-Estradiol receptor, Anti-Nuclear receptor subfamily 3 group A... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 684,00 €
Imlunestrant
Artikelnummer: Cay44974-1
A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S at 100 nM, reduces growth of ER+ T47D and MCF-7 cells (IC50s = 0.34 and 5.2 nM, respectively) but not MDA-MB-231 cells, reduces growth of ERalphaY537S -expressing T47D and MCF-7 cells (IC50s = 113 and 512 nM,...
| Schlagworte: | (5R)-5-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-8-(trifluoromethyl)-H-[1]benzopyrano[4,3-c]quinolin-2-ol |
| Anwendung: | Selective estrogen receptor degrader (SERD) |
| CAS | 2408840-26-4 |
| MW: | 524.52 D |
ab 69,00 €
Methylpiperidino pyrazole (hydrochloride)
Artikelnummer: Cay45218-10
A selective estrogen receptor modulator, an ERalpha antagonist (Ki = 2.7 nM) and is selective for ERalpha over ERbeta (Ki = 1,800 nM), induces apoptosis in RL-95 cells at 1 nM, increases uterine weight in ovariectomized mice at 25, 50, and 100 µg/animal. SMILES:...
| Schlagworte: | MPP, 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-phenol, monohydrochloride |
| Anwendung: | Selective estrogen receptor modulator (SERM) |
| CAS | 2863676-89-3 |
| MW: | 506.04 D |
ab 168,00 €
(E)-4-hydroxy Tamoxifen
Artikelnummer: Cay44830-1
(E)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258, Cay-11629) and (Z)-4-hydroxy tamoxifen (Cay-14854). It is formed from tamoxifen via transisomerization of the (Z)-4-hydroxy tamoxifen intermediate by the cytochrome P450 isoforms CYP1A1, CYP1B1, CYP2B6, CYP2D6, CYP3A4, and CYP3A5. (E)-4-hydroxy...
| Schlagworte: | (E)-Afimoxifene, (E)-4-OHT, cis-4-hydroxy Tamoxifen,... |
| Anwendung: | Active tamoxifen/(Z)-4-hydroxy tamoxifen metabolite, estrogen receptor antagonist |
| CAS | 174592-47-3 |
| MW: | 387.52 D |
ab 35,00 €
Estradiol Undecylate
Artikelnummer: Cay9004927-1
Estradiol undecylate is a synthetic estrogen. It induces vaginal keratinization in ovariectomized rats when administered subcutaneously at a dose of 100 µg/animal. Estradiol undecylate (40 µg/animal) induces vaginal estrus for 80 days in ovariectomized rats. Formal Name: estra-1,3,5(10)-triene-3,17-diol,...
| Schlagworte: | 17beta-Estradiol Undecylate, 17beta-Oestradiol Undecylate, E2 Undecylate, beta-Estradiol Undecylate,... |
| Anwendung: | Synthetic estrogen, estrogen receptor agonist |
| CAS | 3571-53-7 |
| MW: | 440.67 D |
ab 42,00 €
Tamoxifen (citrate)
Artikelnummer: Cay11629-10
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide,... |
| Anwendung: | Estrogen receptor (ER) modulator, Apoptosis inducer |
| CAS | 54965-24-1 |
| MW: | 563.6 D |
ab 69,00 €
Anti-Recombinant Estrogen Receptor alpha, clone 6H7
Artikelnummer: E-AN300734L.100
ESR1(estrogen receptor 1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with...
| Schlagworte: | Anti-ESR1, Anti-ER-alpha, Anti-Estrogen receptor, Anti-Estradiol receptor, Anti-Nuclear receptor subfamily 3 group A... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
Tamoxifen citrate salt
Artikelnummer: CDX-T0201-G001
Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...
| Schlagworte: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide |
| Anwendung: | Selective estrogen receptor modulator |
| CAS | 54965-24-1 |
| MW: | 563,64 D |
ab 85,00 €
Estrogen Receptor Antagonist 2
Artikelnummer: Cay43587-10
Estrogen receptor antagonist 2 is a degrader of estrogen receptor alpha (ERalpha). It induces degradation of ERalpha in MCF-7 breast cancer cells (IC50 = 0.16 nM). Estrogen receptor antagonist 2 inhibits estradiol-induced growth in MCF-7 cells (IC50 = 5.01 nM). In vivo, estrogen receptor antagonist 2 (0.5-50 mg/kg...
| Schlagworte: | AZD9833,... |
| Anwendung: | ERalpha degrader |
| CAS | 2222844-89-3 |
| MW: | 476,52 D |
ab 383,00 €