Zu "K08550" wurden 439 Artikel gefunden!
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Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 101,00 €
NEU
Imlunestrant
Artikelnummer: Cay44974-1
A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S at 100 nM, reduces growth of ER+ T47D and MCF-7 cells (IC50s = 0.34 and 5.2 nM, respectively) but not MDA-MB-231 cells, reduces growth of ERalphaY537S -expressing T47D and MCF-7 cells (IC50s = 113 and 512 nM,...
| Schlagworte: | (5R)-5-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-8-(trifluoromethyl)-H-[1]benzopyrano[4,3-c]quinolin-2-ol |
| Anwendung: | Selective estrogen receptor degrader (SERD) |
| CAS | 2408840-26-4 |
| MW: | 524.52 D |
ab 69,00 €
NEU
Methylpiperidino pyrazole (hydrochloride)
Artikelnummer: Cay45218-10
A selective estrogen receptor modulator, an ERalpha antagonist (Ki = 2.7 nM) and is selective for ERalpha over ERbeta (Ki = 1,800 nM), induces apoptosis in RL-95 cells at 1 nM, increases uterine weight in ovariectomized mice at 25, 50, and 100 µg/animal. SMILES:...
| Schlagworte: | MPP, 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-phenol, monohydrochloride |
| Anwendung: | Selective estrogen receptor modulator (SERM) |
| CAS | 2863676-89-3 |
| MW: | 506.04 D |
ab 168,00 €
(E)-4-hydroxy Tamoxifen
Artikelnummer: Cay44830-1
(E)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258, Cay-11629) and (Z)-4-hydroxy tamoxifen (Cay-14854). It is formed from tamoxifen via transisomerization of the (Z)-4-hydroxy tamoxifen intermediate by the cytochrome P450 isoforms CYP1A1, CYP1B1, CYP2B6, CYP2D6, CYP3A4, and CYP3A5. (E)-4-hydroxy...
| Schlagworte: | (E)-Afimoxifene, (E)-4-OHT, cis-4-hydroxy Tamoxifen,... |
| Anwendung: | Active tamoxifen/(Z)-4-hydroxy tamoxifen metabolite, estrogen receptor antagonist |
| CAS | 174592-47-3 |
| MW: | 387.52 D |
ab 35,00 €
Estradiol Undecylate
Artikelnummer: Cay9004927-1
Estradiol undecylate is a synthetic estrogen. It induces vaginal keratinization in ovariectomized rats when administered subcutaneously at a dose of 100 µg/animal. Estradiol undecylate (40 µg/animal) induces vaginal estrus for 80 days in ovariectomized rats. Formal Name: estra-1,3,5(10)-triene-3,17-diol,...
| Schlagworte: | 17beta-Estradiol Undecylate, 17beta-Oestradiol Undecylate, E2 Undecylate, beta-Estradiol Undecylate,... |
| Anwendung: | Synthetic estrogen, estrogen receptor agonist |
| CAS | 3571-53-7 |
| MW: | 440.67 D |
ab 42,00 €
Anti-Recombinant Estrogen Receptor alpha, clone 6H7
Artikelnummer: E-AN300734L.100
ESR1(estrogen receptor 1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with...
| Schlagworte: | Anti-ESR1, Anti-ER-alpha, Anti-Estrogen receptor, Anti-Estradiol receptor, Anti-Nuclear receptor subfamily 3 group A... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Tamoxifen (citrate)
Artikelnummer: Cay11629-10
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide,... |
| Anwendung: | Estrogen receptor (ER) modulator, Apoptosis inducer |
| CAS | 54965-24-1 |
| MW: | 563.6 D |
ab 69,00 €
Estrogen Receptor Antagonist 2
Artikelnummer: Cay43587-10
Estrogen receptor antagonist 2 is a degrader of estrogen receptor alpha (ERalpha). It induces degradation of ERalpha in MCF-7 breast cancer cells (IC50 = 0.16 nM). Estrogen receptor antagonist 2 inhibits estradiol-induced growth in MCF-7 cells (IC50 = 5.01 nM). In vivo, estrogen receptor antagonist 2 (0.5-50 mg/kg...
| Schlagworte: | AZD9833,... |
| Anwendung: | ERalpha degrader |
| CAS | 2222844-89-3 |
| MW: | 476,52 D |
ab 383,00 €
Tamoxifen citrate salt
Artikelnummer: CDX-T0201-G001
Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...
| Schlagworte: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide |
| Anwendung: | Selective estrogen receptor modulator |
| CAS | 54965-24-1 |
| MW: | 563,64 D |
ab 85,00 €
Fulvestrant
Artikelnummer: Cay10011269-1
Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor alpha (ERalpha). It binds to rat uterine ER with an IC50 value of 44.8 nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06 mg/kg per day) but has no effect on...
| Schlagworte: | ICI 182780, 7alpha-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17beta-diol |
| Anwendung: | ER antagonist |
| CAS | 129453-61-8 |
| MW: | 606.8 D |
ab 51,00 €
Fulvestrant
Artikelnummer: LKT-F8147.5
A synthetic estrogen receptor antagonist. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.
| Anwendung: | Estrogen receptor antagonist |
| CAS | 129453-61-8 |
| MW: | 606,77 D |
ab 100,00 €
Tamoxifen
Artikelnummer: CDX-T0200-G001
Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature...
| Schlagworte: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine |
| Anwendung: | Selective estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371,51 D |
ab 77,00 €