(R)-4-Amino-3-hydroxybutyric Acid

(R)-4-Amino-3-hydroxybutyric acid is a GABA receptor modulator. It binds to GABAA and GABAB receptors (IC50s = 1 and 0.35 µM, respectively) and inhibits GABA uptake in rat brain synaptosomes (IC50 = 67 µM). (R)-4-amino-3-hydroxybutyric acid is also a GABAC receptor agonist that induces currents in a patch-clamp assay using Xenopus oocytes expressing the human receptor (EC50 = 19 µM). In vivo, (R)-4-amino-3-hydroxybutyric acid (20 mg/animal) inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures.Formal Name: (3R)-4-amino-3-hydroxy-butanoic acid. CAS Number: 7013-07-2. Synonyms: L-gamma-Amino-beta-hydroxybutyric Acid, R-(-)-gamma-Amino-beta-hydroxybutyric Acid, (R)-GABOB, (-)-beta-Hydroxy-GABA, (R)-(-)-3-Hydroxy-GABA. Molecular Formula: C4H9NO3. Formula Weight: 119.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC(C[C@@H](O)CN)=O. InChi Code: InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1. InChi Key: YQGDEPYYFWUPGO-GSVOUGTGSA-N.