Quipazine (maleate)

A 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist, induces calcium accumulation in CHO-K1 cells expressing 5-HT2A, 5-HT2B, or 5-HT2C receptors (EC50s = 309.03, 177.83, and 338.84 nM, respectively, for the human receptors), binds to the 5-HT3 receptor (Ki = 2.1 nM), decreases food intake in rats at 2.5, 5, or 10 mg/kg, restores spinal circuitry function, improves gait regularity, and increases interlimb coordination and limb weight-bearing in a rat model of spinal cord transection-induced hindlimb paralysis at 0.3 mg/kg per day in combination with 8-hydroxy DPAT, electrode stimulation of dorsal and lumbar spine regions, and locomotor training. Formulation: A solid. InChI: InChI=1S/C13H15N3.2C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16,2*5-3(6)1-2-4(7)8/h1-6,14H,7-10H2,2*1-2H,(H,5,6)(H,7,8)/b,2*2-1-. InChIKey: VAOSOCRJSSWBEQ-SPIKMXEPSA-N. SMILES: O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCNCC2)=NC3=C(C=CC=C3)C=C1