QS11

Description: QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/beta-catenin signaling pathway to upregulate beta-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells. Target: GTPase, Others. Smiles: OC[C@H](Cc1ccccc1)Nc1nc(Oc2ccc3CCCc3c2)nc2n(Cc3ccc(cc3)-c3ccccc3)cnc12. References: Zhang Q., et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1,104(18):7444-8.