PVP-037

A TLR7/8 agonist adjuvant, induces the production of other cytokines and chemokines, including TNF, IFN-gamma, IL-1ß, and IL-6, in primary human PBMCs at =1 µM, increases anti-rHA IgG titers in mice when used as an adjuvant to rHA. Formulation: A solid. InChI: InChI=1S/C23H22N4O/c1-3-19(17-8-5-4-6-9-17)22(28)25-20-14-18(11-10-16(20)2)21-15-27-13-7-12-24-23(27)26-21/h4-15,19H,3H2,1-2H3,(H,25,28). InChIKey: MMKVSTHRRPPGIO-UHFFFAOYSA-N. SMILES: O=C(C(CC)C1=CC=CC=C1)NC2=C(C)C=CC(C3=CN4C=CC=NC4=N3)=C2