PTP1B-IN-2

PTP1B-IN-2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B, IC50 = 50 nM). It is selective for PTP1B over T cell protein tyrosine phosphatase (TCPTP), Src homology region 2 domain-containing phosphatase 1 (SHP-1), SHP-2, and leukocyte common antigen-related (LAR) phosphatase (IC50s = 760, 2,450, 2,160, and 12,610 nM, respectively). PTP1B-IN-2 (5-20 µM) enhances insulin-induced glucose uptake in L6 myotubes.Formal Name: 5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-benzoic acid, methyl ester. CAS Number: 1919853-46-5. Synonyms: Protein Tyrosine Phosphatase 1B Inhibitor 2, PTPN1 Inhibitor 2, Tyrosine-protein Phosphatase Non-Receptor Type 1 Inhibitor 2. Molecular Formula: C34H36N2O9S2. Formula Weight: 680.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. SMILES: O=C(C1=CC(N(S(=O)(CC2=CC=CC=C2)=O)CC3=CC=C(N(S(=O)(C)=O)CC(OC)=O)C=C3)=CC=C1OCC4=CC=C(C)C=C4)OC. InChi Code: InChI=1S/C34H36N2O9S2/c1-25-10-12-27(13-11-25)23-45-32-19-18-30(20-31(32)34(38)44-3)36(47(41,42)24-28-8-6-5-7-9-28)21-26-14-16-29(17-15-26)35(46(4,39)40)22-33(37)43-2/h5-20H,21-24H2,1-4H3. InChi Key: IPNJQCVHNPGYOX-UHFFFAOYSA-N.