Psora 4

Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3, EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells, EC50s = 25 and 60 nM, respectively).Formal Name: 4-(4-phenylbutoxy)-7H-furo[3,2-g ][1]benzopyran-7-one. CAS Number: 724709-68-6. Molecular Formula: C21H18O4. Formula Weight: 334.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10mg/mL. lambdamax: 217, 251, 269, 310 nm. SMILES: O=C1C=CC2=C(OCCCCC3=CC=CC=C3)C4=C(OC=C4)C=C2O1. InChi Code: InChI=1S/C21H18O4/c22-20-10-9-16-19(25-20)14-18-17(11-13-23-18)21(16)24-12-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-11,13-14H,4-5,8,12H2. InChi Key: JJAWGNIQEOFURP-UHFFFAOYSA-N.