PS-10

A PDHK inhibitor (IC50s = 2.07, 0.8, 21.3, and 0.77 µM for PDHK1, -2, -3, and -4, respectively), selectively binds to PDHK2 over Hsp90 (Kds = 0.239 and 47 µM, respectively), increases heart, liver, and kidney pyruvate dehydrogenase complex activity, decreases blood glucose levels in a glucose tolerance test, and reduces plasma lactate, cholesterol, and triglyceride levels, fat mass, and hepatic lipid accumulation in a mouse model of high-fat diet-induced obesity at 70 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H13NO6S/c16-9-1-2-14(13(19)4-9)22(20,21)15-6-8-3-10(17)5-12(18)11(8)7-15/h1-5,16-19H,6-7H2. InChIKey: SVUZJWAAXPEMKJ-UHFFFAOYSA-N. SMILES: O=S(N1CC2=C(C1)C(O)=CC(O)=C2)(C3=CC=C(O)C=C3O)=O