PROTAC FAK Degrader-1

A PROTAC that drives FAK degradation, reduces the migration and invasion of MDA-MB-231 cells at 50 and 100 nM, respectively. SMILES: O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOC(C=C4)=CC=C4NC(N=C5NCC6=CC(N(C)[S](C)(=O)=O)=CC=C6)=NC=C5C(F)(F)F)=O. InChi Code: InChI=1S/C47H56F3N9O8S2/c1-29-40(68-28-54-29)32-12-10-30(11-13-32)24-52-43(62)38-23-35(60)27-59(38)44(63)41(46(2,3)4)56-39(61)18-19-66-20-21-67-36-16-14-33(15-17-36)55-45-53-26-37(47(48,49)50)42(57-45)51-25-31-8-7-9-34(22-31)58(5)69(6,64)65/h7-17,22,26,28,35,38,41,60H,18-21,23-25,27H2,1-6H3,(H,52,62)(H,56,61)(H2,51,53,55,57)/t35-,38+,41-/m1/s1. InChi Key: MVULIYLBRNHLEE-LFHXYJAASA-N