Propionylpromazine (hydrochloride)

Propionylpromazine is a promazine neuroleptic and dopamine receptor antagonist.{61016, 61012, 61013} It is an antagonist at the I. scapularis (tick) dopamine 2 receptor (Isdop2) and A. aegypti (mosquito) dopamine 2 receptor (AaDOP2), providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM.{61012, 61013} Propionylpromazine inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) but not L. donovani amastigotes or T. cruzi trypomastigotes (ED50s = >30 µM) in mouse peritoneal macrophages. It increases survival of C. elegans in a model of paraquat-induced oxidative stress. Propionylpromazine reduces stereotypic behavior induced by apomorphine in rats (ED50 = 2.5 mg/kg, s.c.). Formulations containing propionylpromazine have been used as tranquilizers in veterinary medicine.Formal Name: 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone, monohydrochloride. CAS Number: 7681-67-6. Molecular Formula: C20H24N2OS . HCl. Formula Weight: 376.9. Purity: >93%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 243, 276 nm. SMILES: O=C(CC)C1=CC=C2SC3=C(N(CCCN(C)C)C2=C1)C=CC=C3.Cl. InChi Code: InChI=1S/C20H24N2OS.ClH/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20,/h5-6,8-11,14H,4,7,12-13H2,1-3H3,1H. InChi Key: ZFWVWZODBGTOIL-UHFFFAOYSA-N.