Probucol

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. Probucol's use is limited, however, because it leads to the reduction of HDL cholesterol as well. Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane. In an in vivo mouse model of Huntington's disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.Formal Name: 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol. CAS Number: 23288-49-5. Synonyms: DH 581, Lorelco, NSC 86225, NSC 652160. Molecular Formula: C31H48O2S2. Formula Weight: 516.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml. lambdamax: 207, 243 nm. SMILES: CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O. InChi Code: InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3. InChi Key: FYPMFJGVHOHGLL-UHFFFAOYSA-N.