Podophyllotoxin

Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities. It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the G2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/ml. Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells. It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 µM). Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide (Cay-12092) and teniposide (Cay-14425). Formulations containing podophyllotoxin have been used in the treatment of external genital warts.Formal Name: (5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS Number: 518-28-5. Synonyms: NSC 24818, (-)-Podophyllotoxin, PPT. Molecular Formula: C22H22O8. Formula Weight: 414.4. Purity: >98%. Formulation: (Request formulation change), A powder. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.14 mg/ml, PBS (pH 7.2): slightly soluble. lambdamax: 294 nm. SMILES: O=C(OC1)[C@]([C@@]1([H])[C@H]2O)([H])C(C3=CC(OC)=C(OC)C(OC)=C3)C4=C2C=C(OCO5)C5=C4. InChi Code: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18?,19-,20-/m0/s1. InChi Key: YJGVMLPVUAXIQN-LBXUKJEYSA-N.