PNU 37883 (hydrochloride)

A KATP channel inhibitor, inhibits SUR2B/Kir6.2 and SUR2B/Kir6.1 (IC50s = 15.2 and 6 µM, respectively) and SUR1/Kir6.2 and SUR2A/Kir6.2 to a lesser extent at 100 µM, inhibits pinacidil-, levcromakalim-, or P1075-induced relaxation of isolated rat middle meningeal arteries at 0.1 and 0.3 µM, increases kallikrein secretion from microdissected connecting tubules isolated from normotensive and spontaneously hypertensive rats, increases sodium excretion and does not affect potassium excretion or glomerular filtration rate in saline-loaded rats at 15 mg/kg. SMILES: C(NC1CCCCC1)(N2CCOCC2)=NC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3.Cl. InChi Code: InChI=1S/C21H35N3O.ClH/c1-2-4-19(5-3-1)22-20(24-6-8-25-9-7-24)23-21-13-16-10-17(14-21)12-18(11-16)15-21,/h16-19H,1-15H2,(H,22,23),1H/t16-,17+,18-,21?,. InChi Key: FZALCKUJYZCDOX-ANWXTAAGSA-N