PLX5622

PLX5622
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay28927-1 1 mg -

6 - 10 Werktage*

35,00 €
Cay28927-5 5 mg -

6 - 10 Werktage*

142,00 €
Cay28927-10 10 mg -

6 - 10 Werktage*

230,00 €
Cay28927-25 25 mg -

6 - 10 Werktage*

369,00 €
 
PLX5622 is a brain-penetrant inhibitor of the colony stimulating factor 1 receptor (CSF1R, IC50 =... mehr
Produktinformationen "PLX5622"
PLX5622 is a brain-penetrant inhibitor of the colony stimulating factor 1 receptor (CSF1R, IC50 = 0.016 µM). It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), Kit, Aurora C, and kinase insert domain receptor (VEGFR2, IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively) and is greater than 100-fold selective for CSF1R over a panel of 230 kinases. PLX5622 (65 mg/kg) reduces the number of Iba-1+ cells, a marker of reduced microglia activation, in the dorsal horn of the spinal cord in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve. It also decreases macrophage levels of TNF-alpha and IL-1beta and infiltration into the sciatic nerve, as well as alleviates mechanical and cold allodynia in the same model. Dietary administration of PLX5622 (1,200 ppm in chow) decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical amyloid-beta (Abeta) plaques in the 5XFAD transgenic mouse model of Alzheimer's disease.Formal Name: 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine. CAS Number: 1303420-67-8. Molecular Formula: C21H19F2N5O. Formula Weight: 395.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/mL, DMSO: 5 mg/mL, DMSO:PBS (pH 7.2) (1:3): 0.2 mg/mL. lambdamax: 227, 291 nm. SMILES: CC1=CN=C(NC=C2CC3=C(F)N=C(NCC4=C(OC)N=CC(F)=C4)C=C3)C2=C1. InChi Code: InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26). InChi Key: NSMOZFXKTHCPTQ-UHFFFAOYSA-N.
Schlagworte: 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine
Hersteller: Cayman Chemical
Hersteller-Nr: 28927

Eigenschaften

Anwendung: CSF1R inhibitor
MW: 395.4 D
Formel: C21H19F2N5O
Reinheit: >98%

Datenbank Information

CAS : 1303420-67-8| Passende Produkte
KEGG ID : K05090 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H315, H319, H335
P-Sätze: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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