PKM2 Inhibitor

PKM2 inhibitor is an inhibitor of pyruvate kinase M2 (PKM2, IC50 = 2.95 µM), a tumor-specific kinase with a role in glycolysis. It is selective for PKM2 over PKM1 and L-type pyruvate kinase (PKLR, IC50s = 16.71 and 8.2 µM, respectively). PKM2 inhibitor is cytotoxic to HCT116, HeLa, and H1299 cells (IC50s = 0.18, 0.29, and 1.56 µM, respectively). It induces apoptosis and autophagy in SKOV3 ovarian cancer cells when used at concentrations of 1, 2.5, and 5 µM. In vivo, PMK2 inhibitor (5 mg/kg) reduces tumor volume and weight in an SKOV3 mouse xenograft model.Formal Name: 1-piperidinecarbodithioic acid, (1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester. CAS Number: 94164-88-2. Synonyms: Compound 3K, MDK4882, PKM2-IN-1, Pyruvate Kinase M2 Inhibitor. Molecular Formula: C18H19NO2S2. Formula Weight: 345.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml. SMILES: O=C1C2=C(C(C(CSC(N3CCCCC3)=S)=C1C)=O)C=CC=C2. InChi Code: InChI=1S/C18H19NO2S2/c1-12-15(11-23-18(22)19-9-5-2-6-10-19)17(21)14-8-4-3-7-13(14)16(12)20/h3-4,7-8H,2,5-6,9-11H2,1H3. InChi Key: STAFOGVMELKGRI-UHFFFAOYSA-N.