Pitavastatin (calcium salt)

Pitavastatin is an HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme). It inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively) and reduces plasma levels of triglycerides and total cholesterol in dogs. Pitavastatin (0.3 mg/kg) increases survival in Dahl salt-sensitive rats fed a high-salt diet, a model of hypertensive heart failure. Formulations containing pitavastatin have been used in the treatment of hyperlipidemia, mixed dyslipidemia, and heterozygous familial hypercholesterolemia.Formal Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt. CAS Number: 147526-32-7. Synonyms: Itabastatin, Itavastatin, NKS 104. Molecular Formula: C25H23FNO4 .1/2Ca. Formula Weight: 440.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml. lambdamax: 245 nm. SMILES: [O-]C(C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=C(C=CC=C3)N=C1C4CC4)=O.[Ca+2]. InChi Code: InChI=1S/C25H24FNO4.Ca/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31,/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31),/q,+2/p-1/b12-11+,/t18-,19-,/m1./s1. InChi Key: VSQHXQMFUCHGBD-NRFPMOEYSA-M.