Pinosylvin

Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities. It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes. Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 µg/ml. It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells. Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis. Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).Formal Name: 5-[(1E)-2-phenylethenyl]-1,3-benzenediol. CAS Number: 22139-77-1. Synonyms: trans-3,5-Dihydroxystilbene. Molecular Formula: C14H12O2. Formula Weight: 212.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:50): 0.01mg/mL, DMSO: 10mg/mL, Ethanol: 20mg/mL, Ethanol:PBS (pH 7.2) (1:50): 0.01mg/mL. lambdamax: 211, 301, 309 nm. SMILES: OC1=CC(/C=C/C2=CC=CC=C2)=CC(O)=C1. InChi Code: InChI=1S/C14H12O2/c15-13-8-12(9-14(16)10-13)7-6-11-4-2-1-3-5-11/h1-10,15-16H/b7-6+. InChi Key: YCVPRTHEGLPYPB-VOTSOKGWSA-N. Origin: Synthetic.