Pinostrobin

Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-alpha and IL-1beta production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 µM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 µM) in a panel of eight cancer cell lines (IC50s = >30 µM).Formal Name: 2,3-dihydro-5-hydroxy-7-methoxy-2S-phenyl-4H-1-benzopyran-4-one. CAS Number: 480-37-5. Molecular Formula: C16H14O4. Formula Weight: 270.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 12 mg/ml. lambdamax: 213, 288 nm. SMILES: COC1=CC(O)=C(C(C[C@@H](C2=CC=CC=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1. InChi Key: ORJDDOBAOGKRJV-AWEZNQCLSA-N.