PIK-293

PIK-293 is a cell-permeable, selective inhibitor of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110delta (IC50s = 100, 25, 10, and 0.24 µM for p110 subunit isoforms alpha, beta, gamma, and delta, respectively).Formal Name: 2-[(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone. CAS Number: 900185-01-5. Molecular Formula: C22H19N7O. Formula Weight: 397.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 227, 271, 311 nm. SMILES: O=C1N(C(CN2C3=NC=NC(N)=C3C=N2)=NC4=CC=CC(C)=C14)C5=C(C)C=CC=C5. InChi Code: InChI=1S/C22H19N7O/c1-13-6-3-4-9-17(13)29-18(27-16-8-5-7-14(2)19(16)22(29)30)11-28-21-15(10-26-28)20(23)24-12-25-21/h3-10,12H,11H2,1-2H3,(H2,23,24,25). InChi Key: KQDBVHKNIYROHU-UHFFFAOYSA-N.