Pifithrin-beta hydrobromide

Description: Pifithrin-beta hydrobromide (Cyclic PFT-alpha) is an inhibitor of p53, reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo, protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 µM). Target: Ferroptosis, p53. Smiles: Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1. References: Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1,19(5):1649-57.