Phenelzine (sulfate)

Phenelzine is an inhibitor of monoamine oxidase (MAO, IC50 = 0.9 µM using rat brain mitochondrial preparations). It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT, Cay-14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Cay-10009019). It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.Formal Name: (2-phenylethyl)-hydrazine, monosulfate. CAS Number: 156-51-4. Synonyms: NSC 170957, W-1544A. Molecular Formula: C8H12N2 . H2SO4. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Water: Slightly Soluble. SMILES: NNCCC1=CC=CC=C1.O=S(O)(O)=O. InChi Code: InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8,1-5(2,3)4/h1-5,10H,6-7,9H2,(H2,1,2,3,4). InChi Key: RXBKMJIPNDOHFR-UHFFFAOYSA-N.