PF429242 dihydrochloride

Description: PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P, with an IC50 of 175 nM. Target: S1P Receptor. Smiles: Cl.Cl.CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1OC)[C@@H]1CCNC1. References: Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep,326(3):801-8.