PF 9601N

PF 9601N is an inhibitor of monoamine oxidase B (MAO-B). It selectively inhibits MAO-B in mouse brain homogenates ex vivo (ID50 = 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 µmol/kg. PF 9601N (0.027 µmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA (Cay-13248) in a rat model of Parkinson's disease induced by 6-OHDA (Cay-25330) when administered at doses of 40 and 60 mg/kg.Formal Name: 5-(phenylmethoxy)-N-2-propyn-1-yl-1H-indole-2-methanamine. CAS Number: 133845-63-3. Molecular Formula: C19H18N2O. Formula Weight: 290.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 20 mg/ml. SMILES: C#CCNCC1=CC2=C(N1)C=CC(OCC3=CC=CC=C3)=C2. InChi Code: InChI=1S/C19H18N2O/c1-2-10-20-13-17-11-16-12-18(8-9-19(16)21-17)22-14-15-6-4-3-5-7-15/h1,3-9,11-12,20-21H,10,13-14H2. InChi Key: YFPNAYXYKXAKJC-UHFFFAOYSA-N.